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The heart may be abnormally giant (cardiomegaly), however affected people usually do not expertise heart failure. The muscle weakness on this disorder leads to serious breathing problems, and most kids with non-traditional infantile-onset Pompe illness dwell only into early childhood. The late-onset type of Pompe disease may not turn into obvious until later in childhood, adolescence, boost blood flow naturally or adulthood. Late-onset Pompe disease is often milder than the infantile-onset types of this disorder and is less likely to involve the heart. Most people with late-onset Pompe disease experience progressive muscle weakness, especially within the legs and the trunk, including the muscles that control breathing. Because the disorder progresses, breathing problems can lead to respiratory failure. Pompe illness impacts about 1 in 40,000 people in the United States. The incidence of this disorder varies among completely different ethnic groups. Mutations in the GAA gene cause Pompe illness. The GAA gene gives instructions for producing an enzyme referred to as acid alpha-glucosidase (also called acid maltase).

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